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NSABP Clinical Trials Overview Protocol B-06 A Protocol to Compare Segmental Mastectomy and Axillary Dissection With and Without Radiation of the Breast and Total Mastectomy and Axillary Dissection Specific Aims To determine in patients with or without clinical axillary node involvement who may be amenable to segmental mastectomy (SM) whether: SM and axillary dissection with or without radiation of the breast is equivalent to total mastectomy plus axillary dissection, cosmetically acceptable preservation of the breast in a subset of patients with primary cancer can be achieved without unfavorably influencing treatment failure and mortality rates as well as morbidity, and to obtain evidence to indicate the clinical significance of microscopic multifocal tumor in the breast.