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NSABP Clinical Trials Overview


Protocol B-15
A Three-Arm Clinical Trial Comparing Short, Intensive Adriamycin-Cyclophosphamide Chemotherapy With and Without Interval Reinduction Chemotherapy (CMF) to "Conventional" CMF in Positive-Node Patients Having The Following Age and Receptor Criteria:
49 Years or younger - All Patients
50-59 Years - PR<10 fmol, regardless of ER


Specific Aims
To determine, in patients with histologically positive axillary nodes who are not classified as tamoxifen-responsive, whether short, intensive adjuvant chemotherapy (AC, with or without interval reinduction with CMF) is as effective as or more effective than "conventional" CMF with respect to disease-free survival and survival.