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Protocol B-22
A Clinical Trial to Evaluate Dose Intensification and Increased Cumulative Dose on Disease-Free Survival and Survival of Primary Breast Cancer Patients with Positive Axillary Nodes Receiving Postoperative Adriamycin-Cyclophosphamide (AC) Therapy
Specific Aims
- To determine whether giving larger but fewer doses of CY (dose intensification) in an AC combination will more effectively prolong disease-free survival and survival than does the same cumulative dose of CY given over a more prolonged period of time.
- To determine whether increasing the dose intensity as well as the cumulative dose of CY (longer administration of a higher dose) will result in greater prolongation of disease-free survival and survival than does giving CY at the same dose intensity but for a shorter period of time (lower cumulative dose).
