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NSABP Clinical Trials Overview Protocol B-23 A Clinical Trial Comparing Short, Intensive AC ± Tamoxifen with Conventional CMF ± Tamoxifen in Node-Negative Breast Cancer Patients with ER-Negative Tumors Specific Aims The specific aims of NSABP Protocol B-23 are: (1) To determine whether four cycles of AC are superior to six cycles of CMF; and (2) to determine whether tamoxifen added to AC or CMF is more efficacious than AC or CMF alone