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NSABP Clinical Trials Overview


Protocol B-25
A Clinical Trial to Evaluate the Effect of Dose Intensification and Increased Cumulative Dose of Postoperative Adriamycin-Cyclophosphamide (AC) Therapy With G-CSF on the Disease-Free Survival and Survival of Patients With Primary Breast Cancer and Positive Axillary Nodes

Specific Aims
  1. To determine whether giving larger but fewer doses of CY (dose intensification) in an AC combination will more effectively prolong disease-free survival and survival than does the same cumulative dose of CY given over a more prolonged period of time.


  2. To determine whether increasing the dose intensity as well as the cumulative dose of CY (longer administration of a higher dose) will result in greater prolongation of disease-free survival and survival than does giving CY at the same dose intensity but for a shorter period of time (lower cumulative dose).