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NSABP Clinical Trials Overview Protocol B-26 A Randomized Trial in Patients with Metastatic or Locally Advanced Breast Cancer Comparing the Effect of 3-Hour vs 24-Hour Infusion of High-Dose Taxol Specific Aims The primary aim of this trial is to compare the response rates of metastatic or locally advanced breast cancer with administration of high-dose Taxol given as 3-hour infusion to the response rates when given as 24-hour infusion. Secondary aims are to compare the two durations of infusion with respect to toxicity, relapse, and survival. If there are no differences in efficacy, the less toxic infusion regimen will be preferable. If there are no differences in toxicity and efficacy, the 3-hour infusion will be preferable.