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NSABP Clinical Trials Overview

Protocol B-38
A Phase III, Adjuvant Trial Comparing Three Chemotherapy Regimens in Women With Node-Positive Breast Cancer: Docetaxel/Doxorubicin/Cyclophosphamide (TAC); Dose-Dense (DD) Doxorubicin/Cyclophosphamide Followed by DD Paclitaxel (DD AC → P); DD AC Followed by DD Paclitaxel Plus Gemcitabine (DD AC → PG)

Specific Aims
The primary aims of the study are to determine whether the DD AC → PG regimen is superior to the TAC regimen as well as to the DD AC → P regimen in improving disease-free survival (DFS) and to compare the relative DFS of TAC and DD AC → P.