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NSABP Clinical Trials Overview

Protocol B-40
A Randomized Phase III Trial of Neoadjuvant Therapy in Patients with Palpable and Operable Breast Cancer Evaluating the Effect on Pathologic Complete Response (pCR) of Adding Capecitabine or Gemcitabine to Docetaxel when Administered Before AC with or without Bevacizumab and Correlative Science Studies Attempting to Identify Predictors of High Likelihood for pCR with Each of the Regimens

Specific Aims
The primary aims of this Phase III study are to determine whether adding capecitabine or gemcitabine to docetaxel followed by AC will increase the pathologic complete response (pCR) rates in patients with palpable and operable HER2-negative breast cancer and to determine whether the addition of bevacizumab to three docetaxel-based regimens followed by AC will increase pCR rates.