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For an electronic/printable version of this overview please click HERE. Protocol C-11 A Phase III Study Evaluating the Role of Perioperative Chemotherapy in Patients with Potentially Resectable Hepatic Colorectal Metastases Specific Aim To evaluate the difference in recurrence-free survival (RFS) between those patients receiving perioperative (preoperative plus postoperative) adjuvant chemotherapy and those receiving only postoperative adjuvant chemotherapy following liver resection for colorectal metastases. ![]() |