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NSABP Clinical Trials Overview Protocol R-01 A Clinical Trial to Evaluate Postoperative Radiation and Postoperative Systemic Chemotherapy in the Management of Resectable Rectal Carcinoma Specific Aims To determine if the disease-free survival and survival of patients having a "curative" resection for rectal carcinoma is improved by (1) the addition of postoperative radiation therapy or (2) the addition of the three-drug regimen, 5-FU, Methyl-CCNU, and vincristine (MOF). This study should also provide information relative to the pathology of rectal cancer that will contribute to greater understanding of the natural history of this disease so that subsets of patients who are at higher risk of recurrence can be identified.